Last Updated: 15 Ocak 2026
Mesotherapy for Dark Spots

Changes in skin tone and uneven pigmentation on the skin surface are commonly referred to as dark spots or skin pigmentation. Some pigmentation issues may be present from birth, but in most cases, they develop over time due to various factors. One of the most common causes is sun exposure-especially UV rays, which can significantly affect the skin.

Sun-related pigmentation can occur in all skin types. In addition, aging is a major factor on its own. As the skin ages, pigmentation may appear not only on the face but also on many other areas of the body. Pregnancy-related pigmentation (melasma) is also very common, and acne or pimples can leave behind post-acne marks and discoloration. Skin damage at different depths may lead to mild, moderate, or deeper pigmentation.

For this reason, it is always beneficial to evaluate what causes the spots. Not every discoloration is simply a sign of aging-sometimes pigmentation may be a clue to an underlying issue. A professional assessment helps define the most effective dark spot treatment strategy for your skin type and needs.

Mesotherapy Treatment for Dark Spots

Today, mesotherapy for pigmentation has become one of the most frequently preferred methods for treating dark spots and achieving a more even complexion. It is considered a highly effective option for many types of pigmentation problems, offering both a safe approach and a high satisfaction rate. Because it is suitable for both women and men, it has become increasingly popular in modern medical aesthetics.

This technique is often chosen not only for acne scars and acne pigmentation, but also for stubborn sun spots that do not fade easily. Another advantage is that it can also be effective for pigmentation that has been present for years.

In dark spot mesotherapy, the skin is supported with customized ingredients selected according to the skin's needs. These specially prepared solutions are delivered into the skin through microinjections. This helps support the skin's natural repair processes and may contribute to a clearer, brighter, healthier-looking complexion.

The substances used in this procedure typically include ingredients the skin needs but may struggle to produce or maintain in adequate amounts. When the skin receives these supportive ingredients in the right concentrations, improvement in pigmentation may become much more achievable.

Dark Spots Are Not Your Destiny

Many people-especially women-may believe that spots caused by acne or hormonal changes will remain permanently. But instead of relying on cosmetics like foundation and concealer for long-term camouflage, it is possible to explore treatments that aim for longer-lasting improvement.

Regardless of the cause, dark spots are not fate. When pigmentation is treated properly, the skin can begin to look smoother, healthier, and more evenly toned. As the injected ingredients start to take effect, many patients notice not only a reduction in visible spots but also an overall improvement in skin quality.

Which Treatments Can Be Combined with Dark Spot Mesotherapy?

For most patients, pigmentation is not the only concern. Many people experience additional skin problems such as dullness, uneven texture, or early aging signs. In such cases, mesotherapy may be planned as part of a combined treatment approach.

Depending on the skin condition, dark spot mesotherapy can be combined with:

  • Topical pigmentation treatments
  • Chemical peeling or enzymatic peeling
  • Skin-brightening creams and medical skincare products
  • Laser treatment for pigmentation
  • PRP (Platelet-Rich Plasma) applications

These methods may be performed in specific intervals according to a personalized treatment plan. Your doctor will determine which combination fits your skin needs and how frequently each method should be applied.

How Many Sessions Are Needed?

One of the most common questions is: How many sessions are required for dark spot mesotherapy? The number of sessions varies from person to person because pigmentation differs in depth, intensity, and distribution, and each skin type reacts differently.

The number of sessions is also influenced by whether other skin conditions are present alongside pigmentation. For many patients, successful outcomes are often achieved in 4 to 6 sessions. However, in some cases, noticeable improvement may occur within 1 to 3 sessions. Rarely, additional sessions beyond six may be needed depending on the stubbornness of pigmentation.

Session intervals are typically planned as one week or two weeks apart. Before starting the procedure, your doctor will inform you about the expected schedule and your personalized session plan.

When Do You See Results?

Many patients hope to see dark spots disappear immediately after treatment, but this is usually not realistic. In most cases, it is necessary to complete at least two sessions before visible improvement begins.

Because the interval between sessions is usually 1-2 weeks, patients generally begin to notice early results after at least two weeks. A more visible reduction in pigmentation often becomes clearer after the third session. This timeline may differ depending on skin type, pigmentation depth, and overall skin response.

What Ingredients Are Used in Dark Spot Mesotherapy?

To choose the most effective ingredients, the skin's needs must be evaluated in detail. The underlying cause of pigmentation is also important. For example, age-related pigmentation may benefit from ingredients that support collagen production and hydration, such as hyaluronic acid.

In some cases, vitamin cocktails may be used to support skin repair and brightness. If pigmentation is related to oily skin, acne, and post-acne marks, other targeted ingredients may be preferred.

The specific formula can vary by patient, but common ingredients used worldwide include:

  • Vitamin C
  • Tranexamic acid
  • Glutathione
  • Skin regenerating agents
  • Antioxidants
  • Retinoic acid
  • Arbutin
  • Multivitamin combinations

The main goal of treatment is to reduce pigmentation and support a clearer skin appearance. These ingredients have been widely tested and are commonly used in medical aesthetics.

Who Should Not Have Dark Spot Mesotherapy?

Although this method is suitable for many people, it may not be recommended for everyone. Dark spot mesotherapy may not be appropriate for:

  • Pregnant women
  • Breastfeeding individuals
  • Patients with a history of stroke
  • Individuals with diabetes
  • Cancer patients
  • People with blood clotting disorders
  • Those with allergies to any ingredient used
  • Patients with urticaria (hives)
  • Individuals with certain heart conditions

Therefore, patients should inform their doctor about existing medical conditions, medications, and previous treatments. This helps determine whether you are a suitable candidate for mesotherapy.

Side Effects of Dark Spot Mesotherapy

After the procedure, mild redness or bruising may occur. These effects are typically temporary and mainly related to the injection process. Even though the treatment is performed with ultra-fine needles, mild redness or bruising may still happen.

The substances used in mesotherapy generally do not enter systemic circulation in a way that causes widespread side effects. Since this method has been used for many years, it is considered a well-established approach in medical aesthetics. For many patients, it offers a safe and effective option to reduce pigmentation and achieve a more even skin tone.

Procedure Process

People who want to get rid of skin discoloration often wonder how this treatment is performed and what the process looks like. The main goal of dark spot mesotherapy is to deliver the skin's needed ingredients through small, frequent doses, using microinjections into targeted areas of pigmentation.

Below are the key steps of the mesotherapy procedure for hyperpigmentation:

  • In mesotherapy for pigmentation, the treatment targets the dark-colored areas that appear on the skin surface.
  • A customized blend of ingredients is injected into the skin to help lighten pigmentation and improve skin tone.
  • The injections are delivered to approximately 4-6 mm below the skin surface, depending on the treatment plan.
  • Before the procedure, a topical numbing cream (anesthetic cream) is applied to reduce discomfort.
  • This numbing cream helps prevent pain, stinging, or sensitivity during treatment.
  • After the injections are completed, patients can usually return to daily life immediately.
  • Dark spot mesotherapy is a non-surgical, outpatient treatment and does not require clinical rest or hospitalization.
  • The injected ingredients may begin supporting skin renewal in a short time, helping the skin recover and brighten gradually.
  • Mild redness may occur in the treated area after the injections.
  • This redness is temporary and typically resolves on its own, so no special intervention is required.

Aftercare

One of the biggest advantages of dark spot mesotherapy (hyperpigmentation mesotherapy) is that most patients can return to work and daily activities shortly after the procedure. For this reason, it is a convenient option for people with a busy schedule who want an effective pigmentation treatment without downtime.

Below are the most important aftercare recommendations following mesotherapy:

  • Patients should always follow the doctor's instructions and warnings after treatment.
  • It is important to avoid any trauma or impact to the treated area.
  • Hygiene rules should be followed carefully to reduce the risk of infection.
  • On the day of the procedure, makeup should not be applied and no cosmetic products should be used on the treated skin.
  • Sun protection is one of the most important steps after dark spot treatment.
  • You can protect your skin by using the sunscreen recommended by your doctor.
  • The procedure does not require special preparation, and there is usually no healing period afterward.
  • After this quick, outpatient treatment, patients can continue their lives normally in a short time.

If you want to reduce visible dark spots and achieve a brighter, clearer complexion, you can benefit from this effective method. Thanks to the active ingredients used in dark spot mesotherapy, achieving a more even skin tone is not just a dream. For detailed information and appointment requests, you can contact us.